Prognostic Value of FDG PET/CT in Patients with Nodal Peripheral T-Cell Lymphoma

Prognostic Value of FDG PET/CT in Patients with Nodal Peripheral T-Cell Lymphoma

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This study evaluated the prognostic significance of FDG PET/CT in patients with nodal peripheral T-cell lymphoma (PTCL).We retrospectively reviewed patients with histologically confirmed nodal PTCL who underwent FDG PET/CT at baseline, after three cycles of first-line chemotherapy (interim), and at the end of therapy.Response was assessed visually using the Deauville 5-point scale (D5PS); scores of 1, 2, and 3 were considered PET-negative, and scores of 4 and 5 were Dice considered PET-positive.

The associations between FDG PET/CT findings and survival were assessed using Cox regression analysis.A total of 79 patients (44 males and 35 females; median age 56 years) were included in this study.In response assessment, 17 (22%) had an interim PET-positive result and 10 (13%) had an end-of-therapy PET-positive result.

During a median follow-up of 50 months, 37 patients (47%) presented with disease read more progression and 30 patients (38%) died.The estimated 5-year progression-free survival (PFS) and overall survival (OS) were 57% and 64%, respectively.An interim PET-positive result was the only significant indicator of PFS.

Higher International Prognostic Index and end-of-therapy PET-positive result were significant independent prognostic factors of OS.Interim and end-of-therapy FDG PET/CT responses based on D5PS are meaningful in predicting the outcomes of patients with nodal PTCL.